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Bio-Techne corporation
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Bioss
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FUJIFILM
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Maixin-Bio ltd
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Bio-Techne corporation
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Image Search Results
Journal: PLoS ONE
Article Title: Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in Mice
doi: 10.1371/journal.pone.0143413
Figure Lengend Snippet: (A) Hepatic expression of IL-1β, IL-10, and CCL2 are significantly decreased (clodronate liposome injection group [ n = 3, only survival] vs. PBS injection group [ n = 4)]). Values are mean ± SEM. * P < 0.05 (Mann-Whitney U test)). (B) Collagen deposition and α-SMA expression are decreased (original magnification, x400). (C) Hepatic expression of TGF-β, Col1α1, and MMP-13 are significantly decreased (clodronate liposome injection group [ n = 3, only survival] vs. PBS injection group [ n = 4]). Values are mean ± SEM. * P < 0.05 (Mann-Whitney U test)).
Article Snippet: For immunohistochemical analysis, liver specimens were fixed in 10% buffered formalin or 4% paraformaldehyde and incubated with rat anti-mouse F4/80 (Clone: A3-1, AbD Serotec, Raleigh, NC, USA), rat anti-mouse CD68 (Clone: FA-11, AbD Serotec), goat anti-mouse Gpnmb (Clone: #297310, R&D Systems, Minneapolis, MN, USA), and
Techniques: Expressing, Injection, MANN-WHITNEY
Journal: PLoS ONE
Article Title: Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in Mice
doi: 10.1371/journal.pone.0143413
Figure Lengend Snippet: (A) Expression of Gpnmb is observed in DBA-g+ but not DBA mice following a single injection of CCl 4 . However, (B) sequential changes in serum ALT levels and the degree of liver injury are not affected by the lack of Gpnmb-positive macrophages (original magnification, x100). Conversely, (C) the areas of fibrosis and (D) the number of α-SMA-positive cells are significantly decreased in the liver tissues of DBA mice compared to DBA-g+ mice (original magnification, x200). Additionally, (E) although lack of Gpnmb-positive macrophages does not affect expression of TGF-β or Col1α1, expression of MMP-9, MMP-13, and TIMP-1 are significantly decreased in mice lacking Gpnmb expression at six or eight days after single injection of CCl 4 . Values are mean ± SEM ( n = 4). * P < 0.05 (Mann-Whitney U test).
Article Snippet: For immunohistochemical analysis, liver specimens were fixed in 10% buffered formalin or 4% paraformaldehyde and incubated with rat anti-mouse F4/80 (Clone: A3-1, AbD Serotec, Raleigh, NC, USA), rat anti-mouse CD68 (Clone: FA-11, AbD Serotec), goat anti-mouse Gpnmb (Clone: #297310, R&D Systems, Minneapolis, MN, USA), and
Techniques: Expressing, Injection, MANN-WHITNEY